| http://purl.uniprot.org/citations/15677469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15677469 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation. Here we report its interaction with activating transcription factor-4 (ATF4), a ubiquitous basic leucine zipper transcription factor important for proliferation, differentiation, and stress response. The C-terminal portion of mitosin between residues 2488 and 3113 bound to ATF4 through two distinct domains, one of which was a leucine zipper motif. Mitosin mutants containing these domains were able to either supershift or disrupt the ATF4-DNA complex. On the other hand, ATF4, but not ATF1-3 or ATF6, interacted with mitosin through a region containing the basic leucine zipper motif. Moreover, overexpression of full-length mitosin repressed the transactivation activity of ATF4 in dual luciferase-based reporter assays, while knocking down mitosin expression manifested the opposite effects. These findings suggest mitosin to be a negative regulator of ATF4 in interphase through direct interaction."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m414310200"xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/author | "Jing N."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/pages | "13973-13977"xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/title | "Mitosin/CENP-F as a negative regulator of activating transcription factor-4."xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15677469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15677469 |
| http://purl.uniprot.org/citations/15677469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15677469 |
| http://purl.uniprot.org/uniprot/P49454#attribution-78B332EE682CE827324F57B0448E3FEA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |
| http://purl.uniprot.org/uniprot/P49454#attribution-9A1FD5DE006434D5D43BCBC1AD5F0BC6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |
| http://purl.uniprot.org/uniprot/Q9GKN4#attribution-4CC923EBFF765CE9BFBD6DB5E5373121 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |
| http://purl.uniprot.org/uniprot/Q9QZ84#attribution-4CC923EBFF765CE9BFBD6DB5E5373121 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |
| http://purl.uniprot.org/uniprot/Q9GKN3#attribution-4CC923EBFF765CE9BFBD6DB5E5373121 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |
| http://purl.uniprot.org/uniprot/Q925D5#attribution-4CC923EBFF765CE9BFBD6DB5E5373121 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15677469 |