| http://purl.uniprot.org/citations/15677484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15677484 | http://www.w3.org/2000/01/rdf-schema#comment | "The vertebrate retina has an area where visual cells are closely packed for proper vision that is known as a fovea, an area centralis or a visual streak. The molecular mechanism that regulates the formation of these structures and visual cell gradients is unknown. The transcription factor Pax6 is a master regulator of eye development. A Pax6 isoform that contains an exon 5a-encoded 14 amino acid insertion in its paired domain, Pax6(+5a), has different DNA-binding properties compared with the Pax6(-5a) isoform. Little is known about the functional significance of Pax6(+5a). Here, we show that Pax6(+5a) is expressed especially in the retinal portion where visual cells accumulate during eye development and, when overexpressed, induces a remarkable well-differentiated retina-like structure. Pax6(+5a) proteins that bear point mutations that are found in patients with foveal hypoplasia are unable to induce these ectopic retina-like structures. We propose that Pax6(+5a) induces a developmental cascade in the prospective fovea, area centralis or visual streak region that leads to the formation of a retinal architecture bearing densely packed visual cells."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddi069"xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Kohsaka S."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Ogura T."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Azuma N."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Kida Y."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Matsushima S."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Shiraishi T."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Asaka A."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Handa H."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Shimamura K."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Tadokoro K."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/author | "Nakafuku M."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/pages | "735-745"xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/title | "The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure."xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15677484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15677484 |
| http://purl.uniprot.org/citations/15677484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15677484 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PRA8-mappedCitation-15677484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677484 |