| http://purl.uniprot.org/citations/15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15680365 | http://www.w3.org/2000/01/rdf-schema#comment | "The differentiation of insulin-producing beta-cells has been investigated in great detail; however, little is known about the factors that delineate the second-most abundant endocrine lineage, the glucagon-producing alpha-cell. Here we utilize a novel YAC-based Foxa3Cre transgene to delete the winged helix transcription factor Foxa2 (formerly HNF-3beta) in the pancreatic primordium during midgestation. The resulting Foxa2(loxP/loxP); Foxa3Cre mice are severely hypoglycemic and die within the first week of life. Mutant mice are hypoglucagonemic secondary to a 90% reduction of glucagon expression. While the number of mature glucagon-positive alpha-cells is dramatically reduced, specification of alpha-cell progenitors is not affected by Foxa2 deficiency. By marker gene analysis, we show that the expression of the alpha-cell transcription factors Arx, Pax6, and Brn4 does not require Foxa2 in the transcriptional hierarchy governing alpha-cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2004.10.012"xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/author | "Lee C.S."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/author | "Kaestner K.H."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/author | "Behr R."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/author | "Sund N.J."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/author | "Herrera P.L."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/pages | "484-495"xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/title | "Foxa2 is required for the differentiation of pancreatic alpha-cells."xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/15680365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15680365 |
| http://purl.uniprot.org/citations/15680365 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15680365 |
| http://purl.uniprot.org/uniprot/P35583#attribution-6F692981C7D73FB88109E3002849BD48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVC9-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_P52946-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_A2AS86-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |
| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-15680365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15680365 |