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http://purl.uniprot.org/citations/15681437http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15681437http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15681437http://www.w3.org/2000/01/rdf-schema#comment"We previously showed that the adenovirus IVa2 and L1 52/55-kDa proteins interact in infected cells and the IVa2 protein is part of two virus-specific complexes (x and y) formed in vitro with repeated elements of the packaging sequence called the A1-A2 repeats. Here we demonstrate that both the IVa2 and L1 52/55-kDa proteins bind in vivo to the packaging sequence and that each protein-DNA interaction is independent of the other. There is a strong and direct interaction of the IVa2 protein with DNA in vitro. This interaction is observed when probes containing the A1-A2 or A4-A5 repeats are used, but it is not found by using an A5-A6 probe. Furthermore, we show that complex x is likely a heterodimer of IVa2 and an unknown viral protein, while complex y is a monomer or multimer of IVa2. No in vitro interaction of purified L1 52/55-kDa protein with the packaging sequence was found, suggesting that the L1 52/55-kDa protein-DNA interaction may be mediated by an intermediate protein. Results support roles for both the L1 52/55-kDa and IVa2 proteins in DNA encapsidation."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.org/dc/terms/identifier"doi:10.1128/jvi.79.4.2366-2374.2005"xsd:string
http://purl.uniprot.org/citations/15681437http://purl.org/dc/terms/identifier"doi:10.1128/jvi.79.4.2366-2374.2005"xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Dus M."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Dus M."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Perez-Romero P."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Perez-Romero P."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Abend J.R."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Abend J.R."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Imperiale M.J."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Imperiale M.J."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Tyler R.E."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/author"Tyler R.E."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/pages"2366-2374"xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/pages"2366-2374"xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/title"Analysis of the interaction of the adenovirus L1 52/55-kilodalton and IVa2 proteins with the packaging sequence in vivo and in vitro."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/title"Analysis of the interaction of the adenovirus L1 52/55-kilodalton and IVa2 proteins with the packaging sequence in vivo and in vitro."xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/volume"79"xsd:string
http://purl.uniprot.org/citations/15681437http://purl.uniprot.org/core/volume"79"xsd:string