| http://purl.uniprot.org/citations/15685448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15685448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15685448 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of an interferon inducible gene 6-16, G1P3, increases not only in type I interferon-treated cells but also in human senescent fibroblasts. However, the function of 6-16 protein is unknown. Here we report that 6-16 is 34 kDa glycosylated protein and localized at mitochondria. Interestingly, 6-16 is expressed at high levels in gastric cancer cell lines and tissues. One of exceptional gastric cancer cell line, TMK-1, which do not express detectable 6-16, is sensitive to apoptosis induced by cycloheximide (CHX), 5-fluorouracil (5-FU) and serum-deprivation. Ectopic expression of 6-16 gene restored the induction of apoptosis and inhibited caspase-3 activity in TMK-1 cells. Thus 6-16 protein has anti-apoptotic function through inhibiting caspas-3. This anti-apoptotic function is expressed through inhibition of the depolarization of mitochondrial membrane potential and release of cytochrome c. By two-hybrid screening, we found that 6-16 protein interacts with calcium and integrin binding protein, CIB/KIP/Calmyrin (CIB), which interacts with presenilin 2, a protein involved in Alzheimer's disease. These protein interactions possibly play a pivotal role in the regulation of apoptosis, for which further detailed analyses are need. These results overall indicate that 6-16 protein may have function as a cell survival protein by inhibiting mitochondrial-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-004-0645-2"xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-004-0645-2"xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Ishihara H."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Ishihara H."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Barrett J.C."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Barrett J.C."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Yamazaki R."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Yamazaki R."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Takeda Y."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Takeda Y."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Naka K."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Naka K."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Ide T."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Ide T."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Matsuzaki T."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Matsuzaki T."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Tahara E."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Tahara E."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Kanno M."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Kanno M."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Tahara H."xsd:string |
| http://purl.uniprot.org/citations/15685448 | http://purl.uniprot.org/core/author | "Tahara H."xsd:string |