http://purl.uniprot.org/citations/15686714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15686714 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionIn vitro studies have shown that apoptotic cell death is triggered by a IL-2-dependent activation of the Fas-FasL pathway and that this pathway can be inhibited by FLIP.MethodsTo define whether FLIP regulates apoptotic death of graft infiltrating T-cells during IL-2-mediated rejection, we analyzed endomyocardial biopsies (EMB) from cardiac allograft recipients for CD3, DNA strand breaks (TUNEL assay), FLIP (mRNA and protein), and FasL mRNA expression.ResultsApoptosis was present in CD3+ T-cell infiltrates. The number of TUNEL-stained mononuclear cells was inversely correlated with FLIP mRNA expression levels (P=.09). FLIP protein was present in 5% to 10% of the infiltrating cells and was constitutively produced by cardiomyocytes irrespective of the rejection grade. Rejection biopsies had elevated IL-2 and FasL mRNA expression levels compared to the expression levels before and after acute rejection (P=.03 and P=.11), while FLIP mRNA expression levels were significantly decreased during rejection (P=.05).ConclusionOur results indicate that during the IL-2-induced rejection process, infiltrated T cells become more sensitive to apoptosis."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.transproceed.2004.11.091"xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "de Weger R.A."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "Niesters H.G."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "Balk A.H."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "Weimar W."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "Baan C.C."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "Zondervan P.E."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/author | "de Groot-Kruseman H.A."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/name | "Transplant Proc"xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/pages | "3143-3148"xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/title | "Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIP."xsd:string |
http://purl.uniprot.org/citations/15686714 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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