| http://purl.uniprot.org/citations/15688398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15688398 | http://www.w3.org/2000/01/rdf-schema#comment | "The outcome of patients with hepatocellular carcinoma (HCC) remains poor because of the high frequency of intrahepatic recurrence (IHR), particularly early IHR within 1 year of hepatectomy. To search for genes involved in early IHR, we performed DNA microarray analysis in a training set of 33 HCCs and selected 46 genes linked to early IHR from approximately 6,000 genes by means of a supervised learning method. Gene selection was validated by a false discovery rate of 0.37%. The 46 genes included many immune response-related genes, which were all downregulated in HCCs with early IHR. Four of these genes (HLA-DRA, HLA-DRB1, HLA-DG and HLA-DQA), encoding MHC class II antigens, were coordinately downregulated in HCCs with early IHR compared to levels in HCCs with nonrecurrence. A cluster analysis reproduced expression patterns of the 4 MHC class II genes in 27 blinded HCC samples. To localize the major site of production of HLA-DR protein in the tumor, we used 50 frozen specimens from 50 HCCs. Immunofluorescence staining showed that HLA-DR protein levels in tumor cells, but not in stromal cells, were associated with the transcription levels of HLA-DRA determined by both DNA microarray analysis and real-time quantitative reverse transcription-PCR. Univariate analysis showed that tumor HLA-DR protein expression, pTNM stage and venous invasion were associated with early IHR. Multivariate analysis showed that tumor HLA-DR protein expression was one of the independent risk factors for early IHR, suggesting HLA-DR protein potential as a biomarker and a molecular target for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.20860"xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Oka M."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Matoba K."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Sakamoto K."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Ishihara T."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Takemoto N."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Yamada-Okabe H."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Iizuka N."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Uchimura S."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Gondo T."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Hamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/author | "Tamesa T."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/pages | "231-240"xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/title | "Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/15688398 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15688398 |
| http://purl.uniprot.org/citations/15688398 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15688398 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15688398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15688398 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15688398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15688398 |