| http://purl.uniprot.org/citations/15688424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15688424 | http://www.w3.org/2000/01/rdf-schema#comment | "The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3. In order to investigate the downstream targets of DDIT3, and the transforming effects of the FUS-DDIT3 fusion protein, we have introduced DDIT3-GFP and FUS-DDIT3-GFP constructs into a human fibrosarcoma cell line. The gene expression profiles of stable transfectants were compared to the original fibrosarcoma cell line by microarray analysis. We here report that the NFkappaB and C/EBP beta controlled gene IL6 is upregulated in DDIT3- and FUS-DDIT3-expressing fibrosarcoma cell lines and in myxoid liposarcoma cell lines. Strong expression of the tumor associated multifunctional cytokine interleukin 6 was confirmed both at mRNA and protein level. Knockdown experiments using siRNA against CEBPB transcripts showed that the effect of FUS-DDIT3 on IL6 expression is C/EBP beta dependent. Chromatin immunoprecipitation revealed direct interaction between the IL6 promoter and the C/EBP beta protein. In addition, the effect of DDIT3 and FUS-DDIT3 on the expression of other acute phase genes was examined using real-time PCR. We demonstrate for the first time that DDIT3 and FUS-DDIT3 show opposite transcriptional regulation of IL8 and suggest that FUS-DDIT3 may affect the synergistic activation of promoters regulated by C/EBP beta and NFkappaB."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.20893"xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Andersson C."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Aman P."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Stahlberg A."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Olofsson A."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Elias E."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/author | "Goransson M."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/pages | "556-560"xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/title | "Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression."xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/15688424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15688424 |
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