| http://purl.uniprot.org/citations/15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15689495 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rab GTPase Ypt1p and the large homodimer Uso1p are both required for tethering endoplasmic reticulum-derived vesicles to early Golgi compartments in yeast. Loss-of-function ypt1 and uso1 mutations are suppressed by SLY1-20, a dominant allele that encodes the Sed5p-associated protein, Sly1p. Here, we investigate the mechanism of SLY1-20 suppression. In wild-type strains, Ypt1p can be coimmunoprecipitated with Uso1p; however, in a ypt1Delta/SLY1-20 strain, which lacks this complex, membrane binding of Uso1p was reduced. In spite of Ypt1p depletion, Uso1p-dependent vesicle tethering was not bypassed under the ypt1Delta/SLY1-20 condition. Moreover, tethering and fusion assays with ypt1Delta/SLY1-20 membranes remained sensitive to Rab GDP dissociation inhibitor. These results indicate that an alternative Rab protein satisfies the Ypt1p requirement in Uso1p-dependent tethering when SLY1-20 is expressed. Further genetic and biochemical tests revealed that a related Rab protein, Ypt6, might substitute for Ypt1p in ypt1Delta/SLY1-20 cells. Additional experimentation to address the mechanism of SLY1-20 suppression in a cog2Delta [sec35Delta] strain indicated that the Cog2p subunit of the conserved oligomeric Golgi complex is either functionally redundant or is not directly required for anterograde transport to the Golgi complex."xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-08-0725"xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/author | "Barlowe C."xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/author | "Ballew N."xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/pages | "1839-1849"xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/title | "A Rab requirement is not bypassed in SLY1-20 suppression."xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15689495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15689495 |
| http://purl.uniprot.org/citations/15689495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15689495 |
| http://purl.uniprot.org/uniprot/P01123#attribution-C0626C69B47B61EC353FE8BBC822D3F5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UN98-mappedCitation-15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/#_P01123-mappedCitation-15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/#_P22213-mappedCitation-15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/#_P25386-mappedCitation-15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/#_P53271-mappedCitation-15689495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/P25386 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/P53271 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/P01123 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/A0A8H8UN98 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689495 |
| http://purl.uniprot.org/uniprot/P22213 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689495 |