| http://purl.uniprot.org/citations/15689518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15689518 | http://www.w3.org/2000/01/rdf-schema#comment | "L-serine dehydratase (SDH), a member of the beta-family of pyridoxal phosphate-dependent (PLP) enzymes, catalyzes the deamination of L-serine and L-threonine to yield pyruvate or 2-oxobutyrate. The crystal structure of L-serine dehydratase from human liver (hSDH) has been solved at 2.5 A-resolution by molecular replacement. The structure is a homodimer and reveals a fold typical for beta-family PLP-dependent enzymes. Each monomer serves as an active unit and is subdivided into two distinct domains: a small domain and a PLP-binding domain that covalently anchors the cofactor. Both domains show the typical open alpha/beta architecture of PLP enzymes. Comparison with the rSDH-(PLP-OMS) holo-enzyme reveals a large structural difference in active sites caused by the artifical O-methylserine. Furthermore, the activity of hSDH-PLP was assayed and it proved to show catalytic activity. That suggests that the structure of hSDH-PLP is the first structure of the active natural holo-SDH."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.041179105"xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/author | "Rao Z."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/author | "Pang H."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/author | "Bartlam M."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/name | "Protein Sci"xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/pages | "791-798"xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/title | "Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver."xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15689518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15689518 |
| http://purl.uniprot.org/citations/15689518 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15689518 |
| http://purl.uniprot.org/uniprot/P20132#attribution-01B2E9777DD8E7534AD1B353EF54DDB1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15689518 |
| http://purl.uniprot.org/uniprot/#_P20132-mappedCitation-15689518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689518 |
| http://purl.uniprot.org/uniprot/#_Q96GA7-mappedCitation-15689518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15689518 |
| http://purl.uniprot.org/uniprot/P20132 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689518 |
| http://purl.uniprot.org/uniprot/Q96GA7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15689518 |