| http://purl.uniprot.org/citations/15691761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15691761 | http://www.w3.org/2000/01/rdf-schema#comment | "Temporal patterning is an important aspect of embryonic development, but the underlying molecular mechanisms are not well understood. Drosophila neuroblasts are an excellent model for studying temporal identity: they sequentially express four genes (hunchback --> Kruppel --> pdm1 --> castor) whose temporal regulation is essential for generating neuronal diversity. Here we show that hunchback --> Kruppel timing is regulated transcriptionally and requires neuroblast cytokinesis, consistent with asymmetric partitioning of transcriptional regulators during neuroblast division or feedback signaling from the neuroblast progeny. Surprisingly, Kruppel --> pdm1 --> castor timing occurs normally in isolated or G(2)-arrested neuroblasts, and thus involves a neuroblast-intrinsic timer. Finally, we find that Hunchback potently regulates the neuroblast temporal identity timer: prolonged Hunchback expression keeps the neuroblast "young" for multiple divisions, and subsequent downregulation allows resumption of Kruppel --> pdm1 --> castor expression and the normal neuroblast lineage. We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2004.11.019"xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/author | "Doe C.Q."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/author | "Pearson B.J."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/author | "Grosskortenhaus R."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/author | "Marusich A."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/pages | "193-202"xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/title | "Regulation of temporal identity transitions in Drosophila neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/15691761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15691761 |
| http://purl.uniprot.org/citations/15691761 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15691761 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF48-mappedCitation-15691761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15691761 |
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