| http://purl.uniprot.org/citations/15692563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15692563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15692563 | http://www.w3.org/2000/01/rdf-schema#comment | "The trafficking of ion channels to the plasma membrane is tightly controlled to ensure the proper regulation of intracellular ion homeostasis and signal transduction. Mutations of polycystin-2, a member of the TRP family of cation channels, cause autosomal dominant polycystic kidney disease, a disorder characterized by renal cysts and progressive renal failure. Polycystin-2 functions as a calcium-permeable nonselective cation channel; however, it is disputed whether polycystin-2 resides and acts at the plasma membrane or endoplasmic reticulum (ER). We show that the subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2, two adaptor proteins that recognize an acidic cluster in the carboxy-terminal domain of polycystin-2. Binding to these adaptor proteins is regulated by the phosphorylation of polycystin-2 by the protein kinase casein kinase 2, required for the routing of polycystin-2 between ER, Golgi and plasma membrane compartments. Our paradigm that polycystin-2 is sorted to and active at both ER and plasma membrane reconciles the previously incongruent views of its localization and function. Furthermore, PACS proteins may represent a novel molecular mechanism for ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600566"xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600566"xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Benzing T."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Benzing T."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Schermer B."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Schermer B."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Walz G."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Walz G."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Tauber R."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Tauber R."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Kramer-Zucker A."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Kramer-Zucker A."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Simmen T."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Simmen T."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Buchholz B."xsd:string |
| http://purl.uniprot.org/citations/15692563 | http://purl.uniprot.org/core/author | "Buchholz B."xsd:string |