| http://purl.uniprot.org/citations/15696169 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15696169 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15696169 | http://www.w3.org/2000/01/rdf-schema#comment | "The proinflammatory cytokine tumor necrosis factor (TNF) modulates cellular responses through the mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappaB) signaling pathways, but the molecular mechanisms underlying MAPK activation are unknown. T cell protein tyrosine phosphatase (TCPTP) is essential for hematopoietic development and negatively regulates inflammatory responses. Using TCPTP-deficient fibroblasts, we show here that TCPTP regulates TNF-induced MAPK but not NF-kappaB signaling. TCPTP interacted with the adaptor protein TRAF2, and dephosphorylated and inactivated Src tyrosine kinases to suppress downstream signaling through extracellular signal-regulated kinases and production of interleukin 6. These results link TCPTP and Src tyrosine kinases to the selective regulation of TNF-induced MAPK signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1169"xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1169"xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Tremblay M.L."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Tremblay M.L."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Sadek C.M."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Sadek C.M."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "van Vliet C."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "van Vliet C."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Tiganis T."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Tiganis T."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Shields B.J."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Shields B.J."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Puryer M.A."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Puryer M.A."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Bukczynska P.E."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/author | "Bukczynska P.E."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/pages | "253-260"xsd:string |
| http://purl.uniprot.org/citations/15696169 | http://purl.uniprot.org/core/pages | "253-260"xsd:string |