| http://purl.uniprot.org/citations/15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15699105 | http://www.w3.org/2000/01/rdf-schema#comment | "Cathepsin E is an aspartic proteinase that has been implicated in Ag processing within the class II MHC pathway. In this study, we document the presence of cathepsin E message and protein in human myeloid dendritic cells, the preeminent APCs of the immune system. Cathepsin E is found in a perinuclear compartment, which is likely to form part of the endoplasmic reticulum, and also a peripheral compartment just beneath the cell membrane, with a similar distribution to that of Texas Red-dextran within 2 min of endocytosis. To investigate the function of cathepsin E in processing, a new soluble targeted inhibitor was synthesized by linking the microbial aspartic proteinase inhibitor pepstatin to mannosylated BSA via a cleavable disulfide linker. This inhibitor was shown to block cathepsin D/E activity in cell-free assays and within dendritic cells. The inhibitor blocked the ability of dendritic cells from wild-type as well as cathepsin D-deficient mice to present intact OVA, but not an OVA-derived peptide, to cognate T cells. The data therefore support the hypothesis that cathepsin E has an important nonredundant role in the class II MHC Ag processing pathway within dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.4.1791"xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Chain B.M."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Terrazzini N."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Free P."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Medd P."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Swetman C."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/author | "Tabor A.B."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/pages | "1791-1800"xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/title | "The expression and function of cathepsin E in dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15699105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15699105 |
| http://purl.uniprot.org/citations/15699105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15699105 |
| http://purl.uniprot.org/uniprot/#_P14091-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_A0A7P0MPN9-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_B4DNU8-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_D3Z6T3-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_F8WIR1-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_Q3TWR6-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_Q3TXL5-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_Q05BF3-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |
| http://purl.uniprot.org/uniprot/#_Q3U8W5-mappedCitation-15699105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699105 |