| http://purl.uniprot.org/citations/15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15699117 | http://www.w3.org/2000/01/rdf-schema#comment | "Through analysis of athymic (nu/nu) mice carrying a transgenic gene encoding GFP instead of RAG-2 product, it has recently been reported that, in the absence of thymopoiesis, mesenteric lymph nodes and Peyer's patches (PP) but not gut cryptopatches are pivotal birthplace of mature T cells such as the thymus-independent intestinal intraepithelial T cells (IEL). To explore and evaluate this important issue, we generated nu/nu mice lacking all lymph nodes (LN) and PP by administration of lymphotoxin-beta receptor-Ig and TNF receptor 55-Ig fusion proteins into the timed pregnant nu/+ mice that had been mated with male nu/nu mice (nu/nu LNP-mice). We also generated nu/nu aly/aly (aly, alymphoplasia) double-mutant mice that inherently lacked all LN, PP, and isolated lymphoid follicles. Although gammadelta-IEL were slightly smaller in number than those in nu/nu mice, substantial colonization of gammadelta-IEL was found to take place in the intestinal epithelia of nu/nu LNP- and nu/nu aly/aly mice. Notably, the population size of a major CD8alphaalpha+ gammadelta-IEL subset was maintained, the use of TCR-gamma-chain variable gene segments by these gammadelta-IEL was unaltered, and the development of cryptopatches remained intact in these nu/nu LNP- and nu/nu aly/aly mice. These findings indicate that all LN, including mesenteric LN, PP, and isolated lymphoid follicles, are not an absolute requirement for the development of gammadelta-IEL in athymic nu/nu mice."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.4.1906"xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Ishikawa H."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Kiyono H."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Hamada H."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Naito T."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Nonaka S."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/author | "Moro K."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/pages | "1906-1912"xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/title | "Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles."xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15699117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15699117 |
| http://purl.uniprot.org/citations/15699117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15699117 |
| http://purl.uniprot.org/uniprot/#_Q32MU3-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_P97313-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_Q3KNY7-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_Q544K4-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_Q61575-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_Q5SYK1-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |
| http://purl.uniprot.org/uniprot/#_Q9WUL6-mappedCitation-15699117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699117 |