| http://purl.uniprot.org/citations/15699166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15699166 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-13 is a major stimulator of inflammation and tissue remodeling at sites of Th2 inflammation. In Th2-dominant inflammatory disorders such as asthma, IL-11 is simultaneously induced. However, the relationship(s) between IL-11 and IL-13 in these responses has not been defined, and the role(s) of IL-11 in the genesis of the tissue effects of IL-13 has not been evaluated. We hypothesized that IL-11, signaling via the IL-11Ralpha-gp130 receptor complex, plays a key role in IL-13-induced tissue responses. To test this hypothesis we compared the expression of IL-11, IL-11Ralpha, and gp130 in lungs from wild-type mice and transgenic mice in which IL-13 was overexpressed in a lung-specific fashion. We simultaneously characterized the effects of a null mutation of IL-11Ralpha on the tissue effects of transgenic IL-13. These studies demonstrate that IL-13 is a potent stimulator of IL-11 and IL-11Ralpha. They also demonstrate that IL-13 is a potent stimulator of inflammation, fibrosis, hyaluronic acid accumulation, myofibroblast accumulation, alveolar remodeling, mucus metaplasia, and respiratory failure and death in mice with wild-type IL-11Ralpha loci and that these alterations are ameliorated in the absence of IL-11Ralpha. Lastly, they provide insight into the mechanisms of these processes by demonstrating that IL-13 stimulates CC chemokines, matrix metalloproteinases, mucin genes, and gob-5 and stimulates and activates TGF-beta1 via IL-11Ralpha-dependent pathways. When viewed in combination, these studies demonstrate that IL-11Ralpha plays a key role in the pathogenesis of IL-13-induced inflammation and remodeling."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.4.2305"xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Lee C.G."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Elias J.A."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Homer R.J."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Rabach L."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/author | "Noble P."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/pages | "2305-2313"xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/title | "IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling."xsd:string |
| http://purl.uniprot.org/citations/15699166 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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