| http://purl.uniprot.org/citations/15699171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15699171 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ T cells are essential for development and perpetuation of Crohn's disease, a chronic immune-mediated condition that affects primarily the small intestine. Using novel models of Crohn's disease-like ileitis (i.e., SAMP1/YitFc and CD4+ T cell transfer models), we have begun to understand the adhesive pathways that mediate lymphocyte trafficking to the chronically inflamed small bowel. Expansion of the CD4/beta7+ population and increased mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression were observed within the intestinal lamina propria with disease progression. However, Ab blockade of the beta7 integrin, the alpha4beta7 heterodimer, MAdCAM-1, or L-selectin did not attenuate inflammation. Blockade of two pathways (L-selectin and MAdCAM-1 or alpha4 integrins) was required to improve ileitis. Further analyses showed that 55 +/-7% of the mesenteric lymph node alpha4beta7+CD4 expressed L-selectin. These L-selectin+ T cells were the main producers of TNF-alpha and the predominant ileitis-inducing subpopulation. Mechanistically, combined blockade of L-selectin and MAdCAM-1 depleted the intestinal lamina propria of CD4+ T cells that aberrantly coexpressed alpha4beta7 and alpha4beta1 integrins, markedly decreasing local production of TNF-alpha and IFN-gamma. Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.4.2343"xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Olson T."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Bamias G."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Cominelli F."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Hoang S."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Bruce A."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Knight R.F."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Rivera-Nieves J."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/author | "Solga M."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/pages | "2343-2352"xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/title | "L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine."xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15699171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15699171 |
| http://purl.uniprot.org/citations/15699171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15699171 |
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| http://purl.uniprot.org/uniprot/#_A0A023IQH3-mappedCitation-15699171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699171 |
| http://purl.uniprot.org/uniprot/#_A0A023IQJ1-mappedCitation-15699171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699171 |
| http://purl.uniprot.org/uniprot/#_B7Z506-mappedCitation-15699171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699171 |
| http://purl.uniprot.org/uniprot/#_B7Z6U6-mappedCitation-15699171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15699171 |