| http://purl.uniprot.org/citations/15700273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15700273 | http://www.w3.org/2000/01/rdf-schema#comment | "Drebrin A is a neuron-specific, actin binding protein. Evidence to date is from in vitro studies, consistently supporting the involvement of drebrin A in spinogenesis and synaptogenesis. We sought to determine whether drebrin A arrives at the plasma membrane of neurons, in vivo, in time to orchestrate spinogenesis and synaptogenesis. To this end, a new antibody was used to locate drebrin A in relation to electron microscopically imaged synapses during early postnatal days. Western blotting showed that drebrin A emerges at postnatal day (PNd) 6 and becomes progressively more associated with F-actin in the pellet fraction. Light microscopy showed high concentrations of drebrin A in the synaptic layers of the hippocampus and cortex. Electron microscopy revealed that drebrin A in these regions is located exclusively in dendrites both neonatally and in adulthood. In adulthood, nearly all of the synaptic drebrin A is within spines forming asymmetric excitatory synapses, verified by gamma-aminobutyric acid (GABA) negativity. At PNd7, patches of drebrin A immunoreactivity were discretely localized to the submembranous surfaces of dendrites forming slight protrusions-protospines. The drebrin A sites exhibited only thin postsynaptic densities and lacked axonal associations or were contacted by axons that contained only a few vesicles. Yet, because of their immunoreactivity to the NR2B subunit of N-methyl-D-aspartate receptors and immunonegativity of axon terminals to GABA, these could be presumed to be nascent, excitatory synapses. Thus, drebrin A may be involved in organizing the dendritic pool of actin for the formation of spines and of axospinous excitatory synapses during early postnatal periods."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.20449"xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Ren Y."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Fujisawa S."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Aoki C."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Sekino Y."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Shirao T."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Mahadomrongkul V."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/author | "Hanamura K."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/pages | "383-402"xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/title | "Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses."xsd:string |
| http://purl.uniprot.org/citations/15700273 | http://purl.uniprot.org/core/volume | "483"xsd:string |
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