| http://purl.uniprot.org/citations/15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15703181 | http://www.w3.org/2000/01/rdf-schema#comment | "The cyclic AMP signal transduction pathway modulates apoptosis in diverse cell types, although the mechanism is poorly understood. A critical component of the intrinsic apoptotic pathway is caspase-9, which is activated by Apaf-1 in the apoptosome, a large complex assembled in response to release of cytochrome c from mitochondria. Caspase-9 cleaves and activates effector caspases, predominantly caspase-3, resulting in the demise of the cell. Here we identified a distinct mechanism by which cyclic AMP regulates this apoptotic pathway through activation of protein kinase A. We show that protein kinase A inhibits activation of caspase-9 and caspase-3 downstream of cytochrome c in Xenopus egg extracts and in a human cell-free system. Protein kinase A directly phosphorylates human caspase-9 at serines 99, 183, and 195. However, mutational analysis demonstrated that phosphorylation at these sites is not required for the inhibitory effect of protein kinase A on caspase-9 activation. Importantly, protein kinase A inhibits cytochrome c-dependent recruitment of procaspase-9 to Apaf-1 but not activation of caspase-9 by a constitutively activated form of Apaf-1. These data indicate that extracellular signals that elevate cyclic AMP and activate protein kinase A may suppress apoptosis by inhibiting apoptosome formation downstream of cytochrome c release from mitochondria."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m414325200"xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Morrice N."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Clarke P.R."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Martin M.C."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Allan L.A."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Sampson C."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/author | "Lickrish M."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/pages | "15449-15455"xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/title | "Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c."xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15703181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15703181 |
| http://purl.uniprot.org/citations/15703181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15703181 |
| http://purl.uniprot.org/uniprot/#_A7E2A2-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TL59-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_A8K8B9-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_A5YM44-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_B7Z708-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_A8K7R5-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_A8K7U6-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_O14727-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |
| http://purl.uniprot.org/uniprot/#_F8VVS7-mappedCitation-15703181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703181 |