| http://purl.uniprot.org/citations/15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15703272 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormalities in subcellular localization and interaction between receptors and their signaling molecules occur within the striatum in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). Synapse-associated proteins (SAPs), for example, PSD-95 and SAP97 organize the molecular architecture of synapses and regulate interactions between receptors and downstream-signaling molecules. Here, we show that expression and subcellular distribution of PSD-95 and SAP97 are altered in the striatum of unilateral 6-OHDA-lesioned rats following repeated vehicle (a model of PD) or L-DOPA administration (a model of L-DOPA-induced dyskinesia). Furthermore, following dopamine-depletion and development of behavioral deficits in Rotorod performance, indicative of parkinsonism, we observed a dramatic decrease in total striatal levels of PSD-95 and SAP97 (to 25.6 +/- 9.9% and 19.0 +/-5.0% of control, respectively). The remaining proteins were redistributed from the synapse into vesicular compartments. L-DOPA (6.5mg/kg twice a day, 21 days) induced a rotational response, which became markedly enhanced with repeated treatment (day 1: -15.8+/-7.3 rotations cf day 21: 758.2+/-114.0 rotations). Post L-DOPA treatment, PSD-95 and SAP97 levels increased (367.4 +/-43.2% and 159.9 +/-9.5% from control values, respectively), with both being redistributed toward synaptic membranes from vesicular compartments. In situ hybridization showed that changes in total levels of PSD-95, but not SAP97, were accompanied by qualitatively similar changes in mRNA. These data highlight the potential role of abnormalities in the subcellular distribution of SAPs in the pathophysiology of a neurological disease."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.04-1854fje"xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/author | "Garner C.C."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/author | "Collingridge G.L."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/author | "Nash J.E."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/author | "Brotchie J.M."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/author | "Johnston T.H."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/pages | "583-585"xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/title | "Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia."xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15703272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15703272 |
| http://purl.uniprot.org/citations/15703272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K7F5-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K1M2-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZQU2-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZVT1-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A0H6-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A2E3-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GC37-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GMS2-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QSM4-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZMM3-mappedCitation-15703272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15703272 |