| http://purl.uniprot.org/citations/15706094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15706094 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased synthesis of heat shock proteins (Hsps), mainly regulated by heat shock factor 1 (Hsf1), protects the heart against oxidative stress under pathophysiological conditions such as ischemia/reperfusion. To investigate whether Hsps might exert a similar protective effect under physiological conditions in the kidney, we first evaluated the HSF1-dependent expression of several Hsps, including Hsp25, alphaB-crystallin (alphaBC), Hsp70, and Hsp90. Unlike either alphaBC or Hsp70, protein expression of Hsp25 and Hsp90 was decreased 26% and 50%, respectively, in Hsf1 knockout compared with the wild-type mice. The effects of Hsp down-regulation on renal cellular redox status are presently unknown. Indeed, HSF1 deficiency caused a 37% decrease in renal cellular GSH/GSSG ratio, a marker of redox status, and a 40% increase in the rate of mitochondrial superoxide generation in Hsf1 knockout compared with wild-type mice. HSF1 disruption also increased mitochondrial permeability transition pore opening and induced greater mitochondrial membrane potential change (48% increase versus wild type). Thus, the present study demonstrates that Hsf1-dependent transcription of selective Hsps is required for normal renal homeostasis, which protects renal cells against oxidative stress under physiological conditions. The source of mitochondrial superoxide generation is discussed."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.org/dc/terms/identifier | "doi:10.1089/ars.2005.7.465"xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/author | "Benjamin I.J."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/author | "Yan L.J."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/author | "Sathyanarayanan S."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/author | "Rajasekaran N.S."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/name | "Antioxid Redox Signal"xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/pages | "465-471"xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/title | "Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney."xsd:string |
| http://purl.uniprot.org/citations/15706094 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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