| http://purl.uniprot.org/citations/15707406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15707406 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have shown an increased expression of several matrix metalloproteinases (MMP) during cardiac, renal and pulmonary allograft rejection. To further define the roles of MMP-2 and MMP-9 in the pathogenesis of cardiac allograft rejection, BALB/c cardiac allografts were transplanted into MMP-2-deficient (-/-) and MMP-9-/-mice. Allografts rejected by wild-type mice revealed a significant increase in MMP-2 and MMP-9 expression. MMP-2-deficiency significantly prolonged allograft survival time. Functioning allografts harvested from MMP-2-/-mice showed lower cellular infiltration and fibrosis than rejected allografts harvested from MMP-2+/+ mice at the same time. In contrast, MMP-9-deficiency significantly decreased allograft survival time. Functioning allografts harvested from MMP-9+/+ mice showed lower cellular infiltration and fibrosis than rejected allografts harvested from MMP-9-/- mice at the same time. MMP-2-/-recipients showed decreased T-cell alloreactivity mediated by a defect in dendritic cell stimulatory and T-cell responsive capacities. In contrast, MMP-9-/-recipients showed increased T-cell alloreactivity mediated by a significant increased in dendritic cell stimulatory and T-cell responsive capacities. These results indicate that MMP2 and MMP-9 play significantly different roles in the process of cardiac allograft rejection."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-6143.2005.00744.x"xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Jaramillo A."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Ramachandran S."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Itohara S."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Shipley J.M."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Rogers J.G."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Senior R.M."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Campbell L.G."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/author | "Moazami N."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/pages | "517-528"xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/title | "Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection."xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15707406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15707406 |
| http://purl.uniprot.org/citations/15707406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15707406 |
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| http://purl.uniprot.org/uniprot/#_Q3TTU7-mappedCitation-15707406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15707406 |
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| http://purl.uniprot.org/uniprot/#_Q3UQ52-mappedCitation-15707406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15707406 |