| http://purl.uniprot.org/citations/15708980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15708980 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeodomain-interacting protein kinase-2 (HIPK2) is a serine/threonine kinase involved in transcriptional regulation and apoptosis. The transcriptional corepressor CtBP (carboxyl-terminal binding protein) also plays a fundamental role in these processes. Our previous studies indicate that HIPK2 participates in a pathway of UV-triggered CtBP clearance that results in cell death. HIPK2 phosphorylates CtBP at Ser-422 in vitro. We developed a Ser-422 phospho-specific antibody to demonstrate that CtBP is phosphorylated on this residue in response to UV irradiation. HIPK2 knock-down blocked the UV-induced Ser-422 phosphorylation and degradation. The proteasomal inhibitor MG-132 treatment increased levels of ubiquitinated CtBP, which was induced by UV. Interference with HIPK2 function via the kinase-dead mutant decreased CtBP ubiquitination. Furthermore, a phosphopeptide spanning Ser-422 blocked UV-triggered CtBP degradation, confirming that Ser-422 phosphorylation marks CtBP for clearance. Consequently, interference with HIPK2 action in H1299 cells rescued UV-triggered apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0409373102"xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/author | "Goodman R.H."xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/author | "Nottke A."xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/pages | "2802-2807"xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/title | "Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15708980 | http://purl.uniprot.org/core/volume | "102"xsd:string |
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