| http://purl.uniprot.org/citations/15713624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15713624 | http://www.w3.org/2000/01/rdf-schema#comment | "Ikaros is a hematopoietic cell-specific zinc finger DNA binding protein that plays an important role in lymphocyte development. Genetic disruption of Ikaros results in T-cell transformation. Ikaros null mice develop leukemia with 100% penetrance. It has been hypothesized that Ikaros controls gene expression through its association with chromatin remodeling complexes. The development of leukemia in Ikaros null mice suggests that Ikaros has the characteristics of a tumor suppressor gene. In this report, we show that the introduction of Ikaros into an established mouse Ikaros null T leukemia cell line leads to growth arrest at the G0/G1 stage of the cell cycle. This arrest is associated with up-regulation of the cell cycle-dependent kinase inhibitor p27kip1, the induction of expression of T-cell differentiation markers, and a global and specific increase in histone H3 acetylation status. These studies provide strong evidence that Ikaros possesses the properties of a bona fide tumor suppressor gene for the T-cell lineage and offer insight into the mechanism of Ikaros's tumor suppressive activity."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.5.1645-1654.2005"xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/author | "Griffiths E."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/author | "Lorenz R."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/author | "Innes A.M."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/author | "Winandy S."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/author | "Kathrein K.L."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/pages | "1645-1654"xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/title | "Ikaros induces quiescence and T-cell differentiation in a leukemia cell line."xsd:string |
| http://purl.uniprot.org/citations/15713624 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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