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http://purl.uniprot.org/citations/15716360http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15716360http://www.w3.org/2000/01/rdf-schema#comment"Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh/+ (tyrosine hydroxylase), and in rats born by Cesarean-section. The functional state of D2, or the high-affinity state for dopamine (D2High), was measured in these supersensitive animal brain striata. Increased levels and higher proportions (40-900%) for D2High were found in all these tissues. If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0409766102"xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"George S.R."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Seeman P."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Robinson S."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Premont R.T."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Palmiter R.D."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Grandy D.K."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Sotnikova T.D."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Quirion R."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Weinshenker D."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Tallerico T."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Bhardwaj S.K."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Srivastava L.K."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Boksa P."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"El-Ghundi M."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Mannisto P.T."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"O'dowd B.F."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/author"Perreault M.L."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/pages"3513-3518"xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/title"Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis."xsd:string
http://purl.uniprot.org/citations/15716360http://purl.uniprot.org/core/volume"102"xsd:string