| http://purl.uniprot.org/citations/15718249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15718249 | http://www.w3.org/2000/01/rdf-schema#comment | "Asthma is a familial inflammatory disease of the airways of the lung. Microbial exposures in childhood protect against asthma through unknown mechanisms. The innate immune system is able to identify microbial components through a variety of pattern-recognition receptors (PRRs). NOD1 is an intracellular PRR that initiates inflammation in response to bacterial diaminopimelic acid (iE-DAP). The NOD1 gene is on chromosome 7p14, in a region that has been genetically linked to asthma. We carried out a systematic search for polymorphism in the gene. We found an insertion-deletion polymorphism (ND(1)+32656) near the beginning of intron IX that accounted for approximately 7% of the variation in IgE in two panels of families (P<0.0005 in each). Allele*2 (the insertion) was associated with high IgE levels. The same allele was strongly associated with asthma in an independent study of 600 asthmatic children and 1194 super-normal controls [odds ratio (OR) 6.3; 95% confidence interval (CI) 1.4-28.3, dominant model]. Differential binding of the two ND(1)+32656 alleles was observed to a protein from nuclei of the Calu 3 epithelial cell line. In an accompanying study, the deletion allele (ND(1)+32656*1) was found to be associated with inflammatory bowel disease. The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddi087"xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Carr D."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Musk A.W."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Fritzsch C."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Hysi P."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Klopp N."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Cookson W.O."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Kabesch M."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Moffatt M.F."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "von Mutius E."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Weiland S.K."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Leupold W."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "James A."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Schedel M."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/author | "Boardman B."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/pages | "935-941"xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/title | "NOD1 variation, immunoglobulin E and asthma."xsd:string |
| http://purl.uniprot.org/citations/15718249 | http://purl.uniprot.org/core/volume | "14"xsd:string |