| http://purl.uniprot.org/citations/15719026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15719026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15719026 | http://www.w3.org/2000/01/rdf-schema#comment | "The envelope glycoprotein complex (Env) of human immunodeficiency virus-1 (HIV-1) can induce apoptosis by a cornucopia of distinct mechanisms. A soluble Env derivative, gp120, can kill cells through signals that are transmitted by chemokine receptors such as CXCR4. Cell surface-bound Env (gp120/gp41), as present on the plasma membrane of HIV-1-infected cells, can kill uninfected bystander cells expressing CD4 and CXCR4 (or similar chemokine receptors, depending on the Env variant) by at least three different mechanisms. First, a transient interaction involving the exchange of lipids between the two interacting cells ('the kiss of death') may lead to the selective death of single CD4-expressing target cells. Second, fusion of the interacting cells may lead to the formation of syncytia which then succumb to apoptosis in a complex pathway involving the activation of several kinases (cyclin-dependent kinase-1, Cdk1; checkpoint kinase-2, Chk2; mammalian target of rapamycin, mTOR; p38 mitogen-activated protein kinase, p38 MAPK; inhibitor of NF-kappaB kinase, IKK), as well as the activation of several transcription factors (NF-kappaB, p53), finally resulting in the activation of the mitochondrial pathway of apoptosis. Third, if the Env-expressing cell is at an early stage of imminent apoptosis, its fusion with a CD4-expressing target cell can precipitate the death of both cells, through a process that may be considered as contagious apoptosis and which does not involve Cdk1, mTOR, p38 nor p53, yet does involve mitochondria. Activation of some of the above-mentioned lethal signal transducers have been detected in patients' tissues, suggesting that HIV-1 may indeed trigger apoptosis through molecules whose implication in Env-induced killing has initially been discovered in vitro."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401584"xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401584"xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Andreau K."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Andreau K."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Castedo M."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Castedo M."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Nardacci R."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Nardacci R."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Perfettini J.-L."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Perfettini J.-L."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Piacentini M."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Piacentini M."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Roumier T."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/author | "Roumier T."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/pages | "916-923"xsd:string |
| http://purl.uniprot.org/citations/15719026 | http://purl.uniprot.org/core/pages | "916-923"xsd:string |