| http://purl.uniprot.org/citations/15721260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15721260 | http://www.w3.org/2000/01/rdf-schema#comment | "In Saccharomyces cerevisiae, telomere replication occurs in late S phase and is accompanied by dynamic remodeling of its protein components. Here, we show that MRX (Mre11-Rad50-Xrs2), an evolutionarily conserved protein complex involved in DNA double-strand break (DSB) repair, is recruited to the telomeres in late S phase. MRX is required for the late S phase-specific recruitment of ATR-like kinase Mec1 to the telomeres. Mec1, in turn, contributes to the assembly of the telomerase regulators Cdc13 and Est1 at the telomere ends. Our results provide a model for the hierarchical assembly of telomere-replication proteins in late S phase; this involves triggering by the loading of MRX onto the chromosome termini. The recruitment of DNA repair-related proteins to the telomeres at particular times in the cell cycle suggests that the normal terminus of a chromosome is recognized as a DSB during the course of replication."xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.01.014"xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/author | "Takata H."xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/author | "Matsuura A."xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/pages | "573-583"xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/title | "Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/15721260 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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