| http://purl.uniprot.org/citations/15721283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15721283 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-inflammatory effect of retinoic acid (RA) has been investigated for several decades. However, the underlying mechanisms responsible for this effect are largely unknown. In this study, we demonstrate that 9-cis-RA (cRA) and all-trans-RA (tRA) inhibit interferon-gamma (IFN-gamma)-induced inflammatory responses in astrocytes. In primary cultured rat brain astrocytes and C6 astroglioma cells, both cRA and tRA decreased IFN-gamma-induced expression of interferon regulatory factor-1. Both RA isoforms also reduced IFN-gamma-induced activation of signal transducers and activators of transcription (STAT)1, STAT3, Janus kinase (JAK)1, and JAK2. This inhibitory effect was significant when cells were pre-treated with RA prior to IFN-gamma. Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement for de novo protein synthesis. Suppressors of cytokine signaling (SOCS), which are negative regulators of the JAK/STAT pathway, may be candidate mediators of the anti-inflammatory function of RA. Both cRA and tRA induced SOCS3 mRNA expression. These results suggest that RA induces an anti-inflammatory effect by suppressing the activation of the JAK/STAT pathway in IFN-gamma-treated astrocytes. SOCS3 may be at least one of the mechanisms that mediate the anti-inflammatory roles of RA."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.01.110"xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Shong M."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Yang M.S."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Jeon S.B."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Choi W.H."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Min K.J."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Joe E.H."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Jou I."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/author | "Ji K.A."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/pages | "125-131"xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/title | "Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://purl.uniprot.org/core/volume | "329"xsd:string |
| http://purl.uniprot.org/citations/15721283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15721283 |
| http://purl.uniprot.org/citations/15721283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15721283 |
| http://purl.uniprot.org/uniprot/P23570#attribution-85989AC2DFCA66482980F9A7716C7714 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15721283 |
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| http://purl.uniprot.org/uniprot/#_Q812C6-mappedCitation-15721283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15721283 |
| http://purl.uniprot.org/uniprot/#_P23570-mappedCitation-15721283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15721283 |
| http://purl.uniprot.org/uniprot/#_Q6DGG4-mappedCitation-15721283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15721283 |
| http://purl.uniprot.org/uniprot/Q812C6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15721283 |