| http://purl.uniprot.org/citations/15721581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15721581 | http://www.w3.org/2000/01/rdf-schema#comment | "Tropoelastin protein monomers associate by coacervation and are cross-linked in vivo to form elastin macro-assemblies. We provide evidence for specific protein domain contact points between tropoelastin monomers during association by coacervation. The homobifunctional cross-linker bis(sulfosuccinimidyl) suberate served as a rapid reporter of adjacent lysines and preferentially exposed domains. Intact cross-linked peptide pairs were identified after protease digestion and high-resolution electrospray mass spectrometry followed by MS/MS sequencing. Mapping of the assigned sequences indicated that the region in the monomer spanning domains 19-25 was readily accessible to solvent and enriched in cross-linking. Domains 12 and 36 were also prevalent, where these two regions were not previously thought to play a major role in the formation of mature elastin. A specificity for particular lysines allowed for the construction of a model for the first close contacts between domains and the first detailed study of the cross-linking of tropoelastin."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2004.11.006"xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/author | "Raftery M.J."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/author | "Weiss A.S."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/author | "Mithieux S.M."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/author | "Wise S.G."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/name | "J Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/pages | "273-281"xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/title | "Specificity in the coacervation of tropoelastin: solvent exposed lysines."xsd:string |
| http://purl.uniprot.org/citations/15721581 | http://purl.uniprot.org/core/volume | "149"xsd:string |
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