| http://purl.uniprot.org/citations/15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15723051 | http://www.w3.org/2000/01/rdf-schema#comment | "A polarity complex of PAR-3, PAR-6 and atypical protein kinase C (aPKC) functions in various cell-polarization events, including neuron specification. The small GTPase Cdc42 binds to PAR-6 and regulates cell polarity. However, little is known about the downstream signals of the Cdc42-PAR protein complex. Here, we found that PAR-3 directly interacted with STEF/Tiam1, which are Rac-specific guanine nucleotide-exchange factors, and that STEF formed a complex with PAR-3-aPKC-PAR-6-Cdc42-GTP. Cdc42 induces lamellipodia in a Rac-dependent manner in N1E-115 neuroblastoma cells. Disruption of Cdc42-PAR-6 or PAR-3-STEF binding inhibited Cdc42-induced lamellipodia but not filopodia. The isolated STEF-binding PAR-3 fragment was sufficient to induce lamellipodia independently of Cdc42 and PAR-6. PAR-3 is required for Cdc42-induced Rac activation, but is not essential for lamellipodia formation itself. In cultured hippocampal neurons, STEF accumulated at the tip of the growing axon and colocalized with PAR-3. The spatio-temporal activation and signalling of Cdc42-PAR-6-PAR-3-STEF/Tiam1-Rac seem to be involved in neurite growth and axon specification. We propose that the PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1, and that this process seems to be required for the establishment of neuronal polarity."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1227"xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Hoshino M."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Nishimura T."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Nabeshima Y."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/author | "Yoshizawa M."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/pages | "270-277"xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/title | "PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1."xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/15723051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15723051 |
| http://purl.uniprot.org/citations/15723051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15723051 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AC12-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_A6IYR8-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_A6IYR9-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_A6JLB5-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_F1LPM7-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_I7GFD1-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |
| http://purl.uniprot.org/uniprot/#_Q6B4M5-mappedCitation-15723051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723051 |