| http://purl.uniprot.org/citations/15723054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15723054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15723054 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Myc coordinates cell growth and division through a transcriptional programme that involves both RNA polymerase (Pol) II- and Pol III-transcribed genes. Here, we demonstrate that human c-Myc also directly enhances Pol I transcription of ribosomal RNA (rRNA) genes. rRNA synthesis and accumulation occurs rapidly following activation of a conditional MYC-ER allele (coding for a Myc-oestrogen-receptor fusion protein), is resistant to inhibition of Pol II transcription and is markedly reduced by c-MYC RNA interference. Furthermore, by using combined immunofluorescence and rRNA-FISH, we have detected endogenous c-Myc in nucleoli at sites of active ribosomal DNA (rDNA) transcription. Our data also show that c-Myc binds to specific consensus elements located in human rDNA and associates with the Pol I-specific factor SL1. The presence of c-Myc at specific sites on rDNA coincides with the recruitment of SL1 to the rDNA promoter and with increased histone acetylation. We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1224"xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1224"xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "White R.J."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "White R.J."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Galloway D.A."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Galloway D.A."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Eisenman R.N."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Eisenman R.N."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Felton-Edkins Z.A."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Felton-Edkins Z.A."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Grandori C."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Grandori C."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Gomez-Roman N."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Gomez-Roman N."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Ngouenet C."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/author | "Ngouenet C."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/pages | "311-318"xsd:string |
| http://purl.uniprot.org/citations/15723054 | http://purl.uniprot.org/core/pages | "311-318"xsd:string |