| http://purl.uniprot.org/citations/15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15723800 | http://www.w3.org/2000/01/rdf-schema#comment | "CDM (CED-5, Dock180, Myoblast city) family members have been recently identified as novel, evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases . They regulate multiple processes, including embryonic development, cell migration, apoptotic-cell engulfment, tumor invasion, and HIV-1 infection, in diverse model systems . However, the mechanism(s) of regulation of CDM proteins has not been well understood. Here, our studies on the prototype member Dock180 reveal a steric-inhibition model for regulating the Dock180 family of GEFs. At basal state, the N-terminal SH3 domain of Dock180 binds to the distant catalytic Docker domain and negatively regulates the function of Dock180. Further studies revealed that the SH3:Docker interaction sterically blocks Rac access to the Docker domain. Interestingly, ELMO binding to the SH3 domain of Dock180 disrupted the SH3:Docker interaction, facilitated Rac access to the Docker domain, and contributed to the GEF activity of the Dock180/ELMO complex. Additional genetic rescue studies in C. elegans suggested that the regulation of the Docker-domain-mediated GEF activity by the SH3 domain and its adjoining region is evolutionarily conserved. This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.01.050"xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Lu M."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Hall M."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Sondek J."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Kinchen J.M."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Grimsley C."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Rossman K.L."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/author | "Yajnik V."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/pages | "371-377"xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/title | "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs."xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15723800 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15723800 |
| http://purl.uniprot.org/citations/15723800 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15723800 |
| http://purl.uniprot.org/uniprot/#_Q14185-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |
| http://purl.uniprot.org/uniprot/#_A4D1X5-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |
| http://purl.uniprot.org/uniprot/#_A0A2X0U2H5-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |
| http://purl.uniprot.org/uniprot/#_B2RUU3-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |
| http://purl.uniprot.org/uniprot/#_B4DVN0-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |
| http://purl.uniprot.org/uniprot/#_B4DJV6-mappedCitation-15723800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15723800 |