| http://purl.uniprot.org/citations/15728469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15728469 | http://www.w3.org/2000/01/rdf-schema#comment | "The Runx family of transcription factors is thought to regulate the differentiation of thymocytes. Runx3 protein is detected mainly in the CD4(-)8(+) subset of T lymphocytes. In the thymus of Runx3-deficient mice, CD4 expression is de-repressed and CD4(-)8(+) thymocytes do not develop. This clearly implicates Runx3 in CD4 silencing, but does not necessarily prove its role in the differentiation of CD4(-)8(+) thymocytes per se. In the present study, we created transgenic mice that overexpress Runx3 and analyzed the development of thymocytes in these animals. In the Runx3-transgenic thymus, the number of CD4(-)8(+) cells was greatly increased, whereas the numbers of CD4(+)8(+) and CD4(+)8(-) cells were reduced. The CD4(-)8(+) transgenic thymocytes contained mature cells with a TCR(high)HSA(low) phenotype. These cells were released from the thymus and contributed to the elevated level of CD4(-)8(+) cells relative to CD4(+)8(-) cells in the spleen. Runx3 overexpression also increased the number of mature CD4(-)8(+) thymocytes in mice with class II-restricted, transgenic TCR and in mice with a class I-deficient background, both of which are favorable for CD4(+)8(-) lineage selection. Thus, Runx3 can drive thymocytes to select the CD4(-)8(+) lineage. This activity is likely to be due to more than a simple silencing of CD4 gene expression."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.5.2627"xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Yoshida N."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Abe N."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Satake M."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Nakazato M."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Habu S."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Kohu K."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/author | "Uchino R."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/pages | "2627-2636"xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/title | "Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage."xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15728469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15728469 |
| http://purl.uniprot.org/citations/15728469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15728469 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-15728469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15728469 |