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| http://purl.uniprot.org/citations/15728586 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about the mechanisms responsible for the fall in fatty acid oxidation during the development of cardiac hypertrophy. We focused on the effects of nuclear factor (NF)-kappaB activation during cardiac hypertrophy on the activity of peroxisome proliferator-activated receptor (PPAR) beta/delta, which is the predominant PPAR subtype in cardiac cells and plays a prominent role in the regulation of cardiac lipid metabolism. Phenylephrine-induced cardiac hypertrophy in neonatal rat cardiomyocytes caused a reduction in the expression of pyruvate dehydrogenase kinase 4 (Pdk4), a target gene of PPARbeta/delta involved in fatty acid utilization, and a fall in palmitate oxidation that was reversed by NF-kappaB inhibitors. Lipopolysaccharide stimulation of NF-kappaB in embryonic rat heart-derived H9c2 myotubes, which only express PPARbeta/delta, caused both a reduction in Pdk4 expression and DNA binding activity of PPARbeta/delta to its response element, effects that were reversed by NF-kappaB inhibitors. Coimmunoprecipitation studies demonstrated that lipopolysaccharide strongly stimulated the physical interaction between the p65 subunit of NF-kappaB and PPARbeta/delta, providing an explanation for the reduced activity of PPARbeta/delta. Finally, we assessed whether this mechanism was present in vivo in pressure overload-induced cardiac hypertrophy. In hypertrophied hearts of banded rats the reduction in the expression of Pdk4 was accompanied by activation of NF-kappaB and enhanced interaction between p65 and PPARbeta/delta. These results indicate that NF-kappaB activation during cardiac hypertrophy down-regulates PPARbeta/delta activity, leading to a fall in fatty acid oxidation, through a mechanism that involves enhanced protein-protein interaction between the p65 subunit of NF-kappaB and PPARbeta/delta."xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m414220200"xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/author | "Planavila A."xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/author | "Laguna J.C."xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/author | "Vazquez-Carrera M."xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/pages | "17464-17471"xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/title | "Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/15728586 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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