| http://purl.uniprot.org/citations/15728677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15728677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15728677 | http://www.w3.org/2000/01/rdf-schema#comment | "Nectins are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules consisting of four members. Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions, including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synaptic junctions in neurons, and Sertoli cell-spermatid junctions in the testis, in cooperation with, or independently of, cadherins. To further explore the function of nectins, we generated nectin 1-/- and nectin 3-/-)mice. Both nectin 1-/- and nectin 3-/-mice showed a virtually identical ocular phenotype, microphthalmia, accompanied by a separation of the apex-apex contact between the pigment and non-pigment cell layers of the ciliary epithelia. Immunofluorescence and immunoelectron microscopy revealed that nectin 1 and nectin 3, but not nectin 2, localized at the apex-apex junctions between the pigment and non-pigment cell layers of the ciliary epithelia. However, nectin 1-/- and nectin 3-/-mice showed no impairment of the apicolateral junctions between the pigment epithelia where nectin 1, nectin 2 and nectin 3 localized, or of the apicolateral junctions between the non-pigment epithelia where nectin 2 and nectin 3, but not nectin 1, localized. These results indicate that the heterophilic trans-interaction between nectin 1 and nectin 3 plays a sentinel role in establishing the apex-apex adhesion between the pigment and non-pigment cell layers of the ciliary epithelia that is essential for the morphogenesis of the ciliary body."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01697"xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01697"xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Irie K."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Irie K."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Inagaki M."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Inagaki M."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Morimoto K."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Morimoto K."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Inoue E."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Inoue E."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Miyoshi J."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Miyoshi J."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Ohtsuka T."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Ohtsuka T."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Tanaka-Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/author | "Tanaka-Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15728677 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |