| http://purl.uniprot.org/citations/15729359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15729359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15729359 | http://www.w3.org/2000/01/rdf-schema#comment | "Netrin-1 receptors UNC5H (UNC5H1-4) were originally proposed to mediate the chemorepulsive activity of netrin-1 during axonal guidance processes. However, UNC5H receptors were more recently described as dependence receptors and, as such, able to trigger apoptosis in the absence of netrin-1. They were also proposed as putative tumor suppressors. Here, we show that UNC5H2 physically interacts with the serine/threonine kinase death-associated protein kinase (DAP-kinase) both in cell culture and in embryonic mouse brains. This interaction occurs in part through the respective death domains of UNC5H2 and DAP-kinase. Moreover, part of UNC5H2 proapoptotic activity occurs through this interaction because UNC5H2-induced cell death is partly impaired in the presence of dominant-negative mutants of DAP-kinase or in DAP-kinase mutant murine embryonic fibroblast cells. In the absence of netrin-1, UNC5H2 reduces DAP-kinase autophosphorylation on Ser308 and increases the catalytic activity of the kinase while netrin-1 blocks UNC5H2-dependent DAP-kinase activation. Thus, the pair netrin-1/UNC5H2 may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600584"xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600584"xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Kimchi A."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Kimchi A."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Gozuacik D."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Gozuacik D."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Llambi F."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Llambi F."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Del Rio G."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Del Rio G."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Guix C."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Guix C."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Lourenco F.C."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Lourenco F.C."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Pays L."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/author | "Pays L."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15729359 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |