| http://purl.uniprot.org/citations/15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15731080 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice with a null deletion mutation in the gamma interferon (IFN-gamma) receptor gene were used to study the role of IFN-gamma responsiveness during experimental pulmonary cryptococcosis. Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor gene (IFN-gammaR-/-) and into control mice (IFN-gammaR+/+). The numbers of CFU in lung, spleen, and brain were determined to assess clearance; cytokines produced by lung leukocytes were measured, and survival curves were generated. In the present study, we demonstrate the following points. (i) IFN-gammaR-/-mice are markedly more susceptible to C. neoformans infection than IFN-gammaR+/+ mice. (ii) In the absence of IFN-gamma signaling, pulmonary CFU continue to increase over the course of infection, and the infection disseminates to the brain. (iii) In the absence of IFN-gamma receptor, recruitment of inflammatory cells in response to pulmonary cryptococcal infection is not impaired. (iv) At week 5 postinfection, IFN-gammaR-/-mice have recruited greater numbers of leukocytes into their lungs, with neutrophils, eosinophils, and lymphocytes accounting for this cellular increase. (v) IFN-gamma signaling is required for the development of a T1 over a T2 immune response in the lung following cryptococcal infection. These results indicate that in the absence of IFN-gamma responsiveness, even though the recruitment of pulmonary inflammatory cells is not impaired and the secretion of IFN-gamma is not affected, IFN-gammaR-/-mice do not have the ability to resolve the cryptococcal infection. In conclusion, our data suggest that proper functional IFN-gamma signaling, possibly through a mechanism which inhibits the potentially disease-promoting T2 response, is required for mice to confine the cryptococcal infection."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.73.3.1788-1796.2005"xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "Chen G.H."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "Huffnagle G.B."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "Lukacs N.W."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "McDonald R.A."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "Toews G.B."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/author | "Wells J.C."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/pages | "1788-1796"xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/title | "The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans."xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/15731080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15731080 |
| http://purl.uniprot.org/citations/15731080 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15731080 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/#_Q540M5-mappedCitation-15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/#_Q3U8T2-mappedCitation-15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/#_Q3TW49-mappedCitation-15731080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/E9PX11 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/P15261 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/Q540M5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15731080 |
| http://purl.uniprot.org/uniprot/Q3TW49 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15731080 |