http://purl.uniprot.org/citations/15731352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15731352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15731352 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear receptors activate transcription by recruiting multiple coactivators to the promoters of specific target genes. The functional synergy of the p160 coactivators [steroid receptor coactivator-1, glucocorticoid receptor interacting protein (GRIP1), or the activator for thyroid hormone and retinoid receptors], the histone acetyltransferases cAMP response element binding protein binding protein (CBP) and p300 and the histone methyltransferase coactivator-associated arginine methyltransferase (CARM1) depends on the methyltransferase activity of CARM1. CARM1 methylates histone H3 and other factors including the N-terminal region of p300. Here, we report that CARM1 also methylates Arg-2142 within the C-terminal GRIP1 binding domain (GBD) of p300. In the GBD, both Arg-2088 and Arg-2142 are important for binding GRIP1. Methylation of Arg-2142 inhibits the bimolecular interaction of GRIP1 to p300 in vitro and in vivo. This methylation mark of p300 GBD is removed by peptidyl deiminase 4, thereby enhancing the p300-GRIP1 interaction. These methylation and demethylimination events also alter the conformation and activity of the coactivator complex and regulate estrogen receptor-mediated transcription, and they thus represent unique mechanisms for regulating coactivator complex assembly, conformation, and function."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0407159102"xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0407159102"xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Lee Y.-H."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Lee Y.-H."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Coonrod S.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Coonrod S.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Kraus W.L."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Kraus W.L."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Jelinek M.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/author | "Jelinek M.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/pages | "3611-3616"xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/pages | "3611-3616"xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/title | "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/title | "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination."xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/volume | "102"xsd:string |
http://purl.uniprot.org/citations/15731352 | http://purl.uniprot.org/core/volume | "102"xsd:string |