| http://purl.uniprot.org/citations/15731358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15731358 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolactin receptor-associated protein (PRAP) originally cloned in our laboratory was shown to be a novel, luteal isoform of 17beta hydroxysteroid dehydrogenase 7 (17betaHSD7). In this study, we cloned the promoter region of rat PRAP/17betaHSD7 and investigated the mechanisms regulating both basal activity and LH-induced repression of this promoter. Truncated and site-specific mutants of PRAP/17betaHSD7 promoter identified two enhancer regions that contained highly conserved Sp1 binding site and bound Sp1 from nuclear extracts of both corpora lutea and a rat luteal cell line. Repression of PRAP/17betaHSD7 expression and promoter activity by human chorionic gonadotropin/forskolin was localized to a -52-bp proximal segment of the promoter. This region contained a conserved CCAAT site and bound nuclear factor Y; binding of this transcription factor was inhibited by human chorionic gonadotropin in vivo. Furthermore, mutation of the nuclear factor Y site in the -52-bp promoter-reporter construct abolished forskolin-mediated inhibition of the promoter in a rat luteal cell line. In summary, we have identified the promoter elements involved in the basal expression of PRAP/17betaHSD7. We have also found that LH-mediated repression of this gene is at the level of transcription and involves inhibition of nuclear factor YA binding to the CCAAT site within the proximal promoter."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2004-1673"xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Gibori G."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Shehu A."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Goldsmith L.T."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Stocco C.O."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Bowen-Shauver J.M."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/author | "Risk M."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/pages | "2807-2816"xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/title | "Cloning and characterization of a 5' regulatory region of the prolactin receptor-associated protein/17{beta} hydroxysteroid dehydrogenase 7 gene."xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/15731358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15731358 |
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