| http://purl.uniprot.org/citations/15731448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15731448 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans. Axonal defects consisted of swellings that accumulated abnormal amounts of microtubule-associated and molecular motor proteins, organelles, and vesicles. Impairing axonal transport by reducing the dosage of a kinesin molecular motor protein enhanced the frequency of axonal defects and increased amyloid-beta peptide levels and amyloid deposition. Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1105681"xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Davies P."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Lillo C."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Masliah E."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Raman R."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Goldstein L.S."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Stokin G.B."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Williams D.S."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Falzone T.L."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Rockenstein E."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Brusch R.G."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/author | "Mount S.L."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/pages | "1282-1288"xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/title | "Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/15731448 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15731448 |
| http://purl.uniprot.org/citations/15731448 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15731448 |
| http://purl.uniprot.org/uniprot/#_E9Q7C9-mappedCitation-15731448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731448 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPZ2-mappedCitation-15731448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731448 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT1-mappedCitation-15731448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731448 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQZ9-mappedCitation-15731448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15731448 |