| http://purl.uniprot.org/citations/15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15733861 | http://www.w3.org/2000/01/rdf-schema#comment | "Tome-1, which refers to a trigger of mitotic entry 1, mediates the destruction of the mitosis-inhibitory kinase, Wee1, via the E3 ligase, SCF. In turn, Tome-1 itself is targeted for degradation by APC in the G1 phase of the cell cycle. In the present study, we analyzed the human and mouse Tome-1 promoter regions. Using synchronized cultures of NIH3T3 cells transfected with Tome-1 promoter/luciferase constructs, we showed that the promoter activity of Tome-1 is activated at the G2/M phase. Using various Tome-1 promoter/luciferase constructs, we showed that the CCAAT box located upstream of the transcription initiation site is important for the basal promoter activity. We identified a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1."xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.01.055"xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/pages | "1488-1492"xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/title | "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters."xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://purl.uniprot.org/core/volume | "579"xsd:string |
| http://purl.uniprot.org/citations/15733861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15733861 |
| http://purl.uniprot.org/citations/15733861 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15733861 |
| http://purl.uniprot.org/uniprot/#_B2R749-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/#_F8WDL1-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/#_F5GX58-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/#_J3KMY0-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/#_Q99M54-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/#_Q99618-mappedCitation-15733861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/J3KMY0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/F5GX58 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/Q99618 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/Q99M54 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/F8WDL1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |
| http://purl.uniprot.org/uniprot/B2R749 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15733861 |