| http://purl.uniprot.org/citations/15734871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15734871 | http://www.w3.org/2000/01/rdf-schema#comment | "Controversial data are available on the association between the retrovirus-like long-terminal repeat (LTR) DQ-LTR13 and genetic susceptibility to type 1 diabetes and other autoimmune diseases. We analyzed DNA samples from 315 type 1 diabetic patients, 166 autoimmune Addison's disease (AAD) patients, 1,054 healthy subjects, and 144 families of type 1 diabetic offspring. DQ-LTR13 was more frequent among patients than healthy subjects (P(c) < 0.0006), and a preferential transmission of DQB1*0302-LTR13(+) from parents to type 1 diabetic offspring was observed. DQ-LTR13 was in linkage disequilibrium (LD) with DQB1*0302 but not DQB1*0201. The presence of DQ-LTR13 increased the odds ratio of DQB1*0302 2.9-to 3.2-fold for type 1 diabetes and AAD. DRB1*0403 was absent in all of the 169 DRB1*04-positive patients but present in 27% (34 of 127) DRB1*04-positive healthy subjects (P(c) < 0.001). DQ-LTR13 was detected in 1 of 34 (3%) DRB1*0403-positive healthy subjects and 36 of 93 (39%) individuals carrying another DRB1*04 allele (P(c) = 0.002). Multivariate logistic regression analysis revealed that DQ-LTR13 is not independently associated with type 1 diabetes and AAD after correction for DQB1*0302 and DRB1*0403. Conversely, DQB1*0201, DQB1*0302, DRB1*0401, and DRB1*0403 were all significantly associated with disease risk also after correction for DQ-LTR13. We provide conclusive evidence that the genetic association of DQ-LTR13 with type 1 diabetes and AAD is primarily due to a LD with DQB1*0302 and DRB1*0403."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.54.3.900"xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Kockum I."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Betterle C."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Libe R."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Giordano R."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Falorni A."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Gambelunghe G."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Bini V."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "Celi F."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/author | "De Giorgi G."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/pages | "900-905"xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/title | "Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease."xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/15734871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15734871 |
| http://purl.uniprot.org/citations/15734871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15734871 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15734871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15734871 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15734871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15734871 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15734871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15734871 |
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| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-15734871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15734871 |