| http://purl.uniprot.org/citations/15735649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15735649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15735649 | http://www.w3.org/2000/01/rdf-schema#comment | "The p38 MAP kinase (MAPK) is phosphorylated and activated by upstream MAPK kinases. T cells have an alternative pathway in which T cell receptor-activated tyrosine kinase Zap70 phosphorylates p38 on Tyr323. Mice lacking Gadd45alpha, a small p38-binding molecule, develop a lupus-like autoimmune disease. Here we show that resting T cells but not B cells from Gadd45a(-/-) mice had spontaneously increased p38 activity in the absence of 'upstream' MAPK kinase activation. The p38 from resting Gadd45a(-/-) T cells was spontaneously phosphorylated on Tyr323, and its activity was specifically inhibited by recombinant Gadd45alpha in vitro. Thus, constitutive activation of T cell p38 through the alternative pathway is prevented by Gadd45alpha, the absence of which results in p38 activation, T cell hyperproliferation and autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1176"xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1176"xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Belova G.I."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Belova G.I."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Fornace A.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Fornace A.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Mittelstadt P.R."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Mittelstadt P.R."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Salvador J.M."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/author | "Salvador J.M."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/pages | "396-402"xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/pages | "396-402"xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/title | "The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/title | "The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15735649 | http://purl.uniprot.org/core/volume | "6"xsd:string |