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| http://purl.uniprot.org/citations/15737744 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the roles of netrin-1 and slit-2 in regulation and navigation of dopamine (DA) axon growth using an explant culture preparation of embryonic ventral midbrain (embryonic day 14) and a co-culture system. We found that netrin-1 protein significantly enhanced DA axonal outgrowth and promoted DA axonal outgrowth in a co-culture system of netrin-1 expressing cells. Such effects were mediated by the receptor DCC as demonstrated by antibody perturbation of the DCC receptor. In contrast, slit-2 inhibited DA neuron extensions and repelled DA neurite growth. These slit-2 activities required robo receptors since the reduced neurite extension was abolished by addition of excess robo receptors. In this system, netrin-1 stimulated and slit-2 opposed DA neurite growth. Such regulation may be important for DA axonal maintenance, regeneration, and phenotypic target recognition."xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2004.11.009"xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/author | "Isacson O."xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/pages | "547-555"xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/title | "Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons."xsd:string |
| http://purl.uniprot.org/citations/15737744 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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