| http://purl.uniprot.org/citations/15737928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15737928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15737928 | http://www.w3.org/2000/01/rdf-schema#comment | "The let-7 microRNA is phylogenetically conserved and temporally expressed in many animals. C. elegans let-7 controls terminal differentiation in a stem cell-like lineage in the hypodermis, while human let-7 has been implicated in lung cancer. To elucidate let-7's role in temporal control of nematode development, we used sequence analysis and reverse genetics to identify candidate let-7 target genes. We show that the nuclear hormone receptor daf-12 is a let-7 target in seam cells, while the forkhead transcription factor pha-4 is a target in the intestine. Additional likely targets are the zinc finger protein die-1 and the putative chromatin remodeling factor lss-4. Together with the previous identification of the hunchback ortholog hbl-1 as a let-7 target in the ventral nerve cord, our findings show that let-7 acts in at least three tissues to regulate different transcription factors, raising the possibility of let-7 as a master temporal regulator."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2004.12.019"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2004.12.019"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Gerstein M."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Gerstein M."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Johnson T."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Johnson T."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Slack F.J."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Slack F.J."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Grosshans H."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Grosshans H."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Reinert K.L."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/author | "Reinert K.L."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/pages | "321-330"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/pages | "321-330"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/title | "The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/title | "The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/15737928 | http://purl.uniprot.org/core/volume | "8"xsd:string |