| http://purl.uniprot.org/citations/15741237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15741237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15741237 | http://www.w3.org/2000/01/rdf-schema#comment | "Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals of hippocampus, nectin-1 and nectin-3 localize at the presynaptic and postsynaptic sides of synaptic junctions, respectively, and their trans-interactions play a role in formation of synapses in cooperation with N-cadherin. Nectins are associated with the actin cytoskeleton through afadin, a nectin- and actin-filament-binding protein. Five nectin-like molecules (Necls) which have domain structures similar to those of nectins have been identified and here we characterize Necl-1/TSLL1/SynCAM3, from now on referred to as Necl-1. Tissue distribution analysis showed that Necl-1 was specifically expressed in the neural tissue. Immunofluorescence and immunoelectron microscopy revealed that Necl-1 localized at the contact sites among axons, their terminals, and glia cell processes that cooperatively formed synapses, axon bundles and myelinated axons. Necl-1 showed Ca2+-independent homophilic cell-cell adhesion activity. It furthermore showed Ca2+-independent heterophilic cell-cell adhesion activity with Necl-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 from now on referred to as Necl-2, nectin-1 and nectin-3, but not with Necl-5 or nectin-2. The C-terminal cytoplasmic region of Necl-1 did not bind afadin but bound membrane-associated guanylate kinase subfamily members that contain the L27 domain, including Dlg3, Pals2 and CASK. These results indicate that Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01656"xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01656"xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Ikeda W."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Ikeda W."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Ohtsuka T."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Ohtsuka T."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Deguchi-Tawarada M."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Deguchi-Tawarada M."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Kakunaga S."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/author | "Kakunaga S."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/pages | "1267-1277"xsd:string |
| http://purl.uniprot.org/citations/15741237 | http://purl.uniprot.org/core/pages | "1267-1277"xsd:string |