| http://purl.uniprot.org/citations/15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15744305 | http://www.w3.org/2000/01/rdf-schema#comment | "The 'help' provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antigen. Once primed in the presence of CD4+ T cells, 'helped' CD8+ T cells acquire the ability to undergo a second round of clonal expansion upon restimulation in the absence of T-cell help. 'Helpless' CD8+ T cells that are primed in the absence of CD4+ T cells, in contrast, can mediate effector functions such as cytotoxicity and cytokine secretion upon restimulation, but do not undergo a second round of clonal expansion. These disparate responses have features of being 'programmed', that is, guided by signals that are transmitted to naive CD8+ T cells during priming, which encode specific fates for their clonal progeny. Here we explore the instructional programme that governs the secondary response of CD8+ T cells and find that helpless cells undergo death by activation-induced cell death upon secondary stimulation. This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03337"xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Griffith T.S."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Bensinger S.J."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Janssen E.M."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Pinkoski M.J."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Schoenberger S.P."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Droin N.M."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Lemmens E.E."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/author | "Ehst B.D."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/pages | "88-93"xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/title | "CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://purl.uniprot.org/core/volume | "434"xsd:string |
| http://purl.uniprot.org/citations/15744305 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15744305 |
| http://purl.uniprot.org/citations/15744305 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15744305 |
| http://purl.uniprot.org/uniprot/#_A0A0U5CJG6-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |
| http://purl.uniprot.org/uniprot/#_G3UY25-mappedCitation-15744305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15744305 |