| http://purl.uniprot.org/citations/15746179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15746179 | http://www.w3.org/2000/01/rdf-schema#comment | "Atrogin1/MAFbx is an ubiquitin ligase that mediates muscle atrophy in a variety of catabolic states. We recently found that H2O2 stimulates atrogin1/MAFbx gene expression. Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway, we hypothesized that TNF-alpha would also increase atrogin1/MAFbx gene expression. As with H2O2, we found that TNF-alpha exposure up-regulates atrogin1/MAFbx mRNA within 2 h in C2C12 myotubes. Intraperitoneal injection of TNF-alpha increased atrogin1/MAFbx mRNA in skeletal muscle of adult mice within 4 h. Exposing myotubes to either TNF-alpha or H2O2 also produced general activation of the mitogen-activated protein kinases (MAPKs): p38, ERK1/2, and JNK. The increase in atrogin1/MAFbx gene expression induced by TNF-alpha was not altered significantly by ERK inhibitor PD98059 or the JNK inhibitor SP600125. In contrast, atrogin1/MAFbx up-regulation and the associated increase in ubiquitin conjugating activity were both blunted by p38 inhibitors, either SB203580 or curcumin. These data suggest that TNF-alpha acts via p38 to increase atrogin1/MAFbx gene expression in skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.04-2364com"xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Li Y.P."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Reid M.B."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Mann D.L."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "John J."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Reid M.B.'"xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/author | "Moylan J."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/pages | "362-370"xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/title | "TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15746179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15746179 |
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| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-15746179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746179 |
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