| http://purl.uniprot.org/citations/15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15746428 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor kappaB (NF-kappaB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. Caspase-8 also causes the alphabeta complex of the inhibitor of NF-kappaB kinase (IKK) to associate with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex. Recruitment of the IKKalpha, beta complex, its activation, and the nuclear translocation of NF-kappaB require enzyme activity of full-length caspase-8. These findings thus explain the paradoxical association of defective apoptosis and combined immunodeficiency in human CED."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1104765"xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Dale J."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Sakai K."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Su H."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Hakem R."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Lenardo M."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Salmena L."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Bidere N."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Cubre A."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/author | "Straus S."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/pages | "1465-1468"xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/title | "Requirement for caspase-8 in NF-kappaB activation by antigen receptor."xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/15746428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15746428 |
| http://purl.uniprot.org/citations/15746428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15746428 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746428 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746428 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746428 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746428 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-15746428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15746428 |